KLHDC2-BRD4 PROTAC K2-B4-5e

Chemical Structure : KLHDC2-BRD4 PROTAC K2-B4-5e

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货号: PC-22819Not For Human Use, Lab Use Only.

KLHDC2-BRD4 PROTAC K2-B4-5e is a hihgly potent KLHDC2-directed PROTAC degrader of BRD4 with DC50 of 6.2 nM against HiBiT-BRD4, Dmax=93%, in PC-3 cells.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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KLHDC2-BRD4 PROTAC K2-B4-5e is a hihgly potent KLHDC2-directed PROTAC degrader of BRD4 with DC50 of 6.2 nM against HiBiT-BRD4, Dmax=93%, in PC-3 cells.

物理化学性质&存储条件

分子量	949.52
分子式	C52H49ClN8O6S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	methyl (S)-2-(5-(7-(4'-(2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetamido)-[1,1'-biphenyl]-4-carbonyl)-3-isobutyl-2-oxo-5,6,7,8-tetrahydro-1,7-naphthyridin-1(2H)-yl)-2-oxopyridin-1(2H)-yl)acetate

参考文献

1. Hickey CM, et al. Nat Struct Mol Biol. 2024 Feb;31(2):311-322.