KDU731 | Cryptosporidium PI4K inhibitor | Probechem Biochemicals

Chemical Structure : KDU731

CAS No.: 1610610-48-4

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KDU731 (KDU 731)

货号: PC-62150Not For Human Use, Lab Use Only.

KDU731 is a potent, selective parasite Cryptosporidium lipid kinase PI4K (phosphatidylinositol-4-OH kinase) inhibitor with IC50 of 25 nM, displays >50-fold selectivity window against the human PI4K IIIβ homologue.

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5 mg	￥2480	In stock
10 mg	￥3980	In stock
25 mg	￥5980	In stock
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100 mg		Get quote

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生物&药学活性

KDU731 is a potent, selective parasite Cryptosporidium lipid kinase PI4K (phosphatidylinositol-4-OH kinase) inhibitor with IC50 of 25 nM, displays >50-fold selectivity window against the human PI4K IIIβ homologue.
KDU731 shows HepG2 CC50 of 15.6 uM and C. parvum CPE EC50 of 0.1 uM.
KDU731 demonstrates a potent reduction in intestinal infection of immunocompromised mice after oral treatment, also leads to rapid resolution of diarrhoea and dehydration in neonatal calves, a clinical model of cryptosporidiosis that closely resembles human infection.

物理化学性质&存储条件

分子量	396.41
分子式	C22H16N6O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(4-carbamoylphenyl)-N-(5-cyanopyridin-2-yl)-N-methylpyrazolo[1,5-a]pyridine-5-carboxamide

参考文献

1. Manjunatha UH, et al. Nature. 2017 Jun 15;546(7658):376-380.

2. Ward HD. Trends Parasitol. 2017 Sep;33(9):662-664.

KDU731 (KDU 731)

生物&药学活性

物理化学性质&存储条件

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KDU731 (KDU 731)

生物&药学活性

物理化学性质&存储条件

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