JYQ-194 | PARK7 degrader | Probechem Biochemicals

Chemical Structure : JYQ-194

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JYQ-194 (JYQ194)

货号: PC-22303Not For Human Use, Lab Use Only.

JYQ-194 (JYQ194) is a first-in-class, selective PARK7 PROTAC degrader, induces degradation of PARK7 starting at 0.1 uM and reaching a Dmax of 80% at a concentration of 5 uM in A549 cells.

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生物&药学活性

JYQ-194 (JYQ194) is a first-in-class, selective PARK7 PROTAC degrader, induces degradation of PARK7 starting at 0.1 uM and reaching a Dmax of 80% at a concentration of 5 uM in A549 cells.
JYQ-194 induces PARK7 degradation in multiple tumor cell lines, via ubiquitin/proteasome system-dependent action.

物理化学性质&存储条件

分子量	903.92
分子式	C39H38FN11O10S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3R)-1-cyano-N-(5-(5-((4-((2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)methyl)-1H-1,2,3-triazol-1-yl)sulfonyl)-2-fluorobenzoyl)-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)pyrrolidine-3-carboxamide

参考文献

1. Jia Y, et al. J Med Chem. 2024 May 7. doi: 10.1021/acs.jmedchem.3c02410.

JYQ-194 (JYQ194)

生物&药学活性

物理化学性质&存储条件

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JYQ-194 (JYQ194)

生物&药学活性

物理化学性质&存储条件

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