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首页-小分子抑制剂&激动剂-GPCR-Sigma Receptor-JVW-1034
JVW-1034

Chemical Structure : JVW-1034

CAS No.:

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JVW-1034 (JVW1034)

货号: PC-63494Not For Human Use, Lab Use Only.

JVW-1034 is a selective small molecule modulator of σ2R/Tmem97 with Ki of 23 nM, 10-fold weaker affinity for σ1R (Ki=248 nM).

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

JVW-1034 is a selective small molecule modulator of σ2R/Tmem97 with Ki of 23 nM, 10-fold weaker affinity for σ1R (Ki=248 nM).
JVW-1034 reduces alcohol withdrawal behavior via an ortholog of σ2R/TMEM97.
JVW-1034 significantly reduces excessive alcohol drinking selectively in alcohol-dependent rats, without affecting alcohol drinking in non-dependent rats.

物理化学性质&存储条件

分子量 311.853
分子式 C20H22ClN
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

9-chloro-2-phenethyl-1,2,3,4,5,6-hexahydro-1,6-methanobenzo[c]azocine

参考文献

1. Scott LL, et al. Neuropsychopharmacology. 2018 Apr 20. doi: 10.1038/s41386-018-0067-z.

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