JTE 013 |CAS:547756-93-4 Probechem Biochemicals

Chemical Structure : JTE 013

CAS No.: 547756-93-4

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JTE 013 (JTE-013;JTE013)

货号: PC-60745Not For Human Use, Lab Use Only.

JTE-013 (JTE013) is a potent, specific S1P2 receptor (Edg-5) antagonist with IC50 of 17 nM and 22 nM for human and rat S1P2, respectively.

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5 mg	￥1380	In stock
10 mg	￥2180	In stock
25 mg	￥3780	In stock
100 mg		Get quote

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生物&药学活性

JTE-013 (JTE013) is a potent, specific S1P2 receptor (Edg-5) antagonist with IC50 of 17 nM and 22 nM for human and rat S1P2, respectively.
JTE-013 does not affect S1P binding to S1P3 and S1P1 at 10 uM.
JTE-013 inhibits not only S1P-induced vasoconstriction, but also KCl-, U46619- and endothelin-1-induced constriction in vivo.
JTE-013 abrogates S1P induced inhibition and activation, respectively, of Rac and RhoA in B16 cells.

物理化学性质&存储条件

分子量	408.29
分子式	C17H19N7OCl2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-[1,3-Dimethyl-4-(2-methylethyl)-1H-pyrazolo[3,4-b]pyridin-6-yl]-4-(3,5-dichloro-4-pyridinyl)-semicarbazide

参考文献

1. Li MH, et al. J Pharmacol Exp Ther. 2015 Sep;354(3):261-8.

2. Ohmori T, et al. Cardiovasc Res. 2003 Apr 1;58(1):170-7.

3. Arikawa K, et al. J Biol Chem. 2003 Aug 29;278(35):32841-51.

4. Ohmori T, et al. J Thromb Haemost. 2004 Jan;2(1):203-5.

JTE 013 (JTE-013;JTE013)

生物&药学活性

物理化学性质&存储条件

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JTE 013 (JTE-013;JTE013)

生物&药学活性

物理化学性质&存储条件

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