JT001 | NLRP3 inhibitor | Probechem Biochemicals

Chemical Structure : JT001

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JT001 (JT-001)

货号: PC-20912Not For Human Use, Lab Use Only.

JT001 (JT-001) is a potent, highly specific NLRP3 inhibitor, inhibits NLRP3 inflammasome assembly.

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生物&药学活性

JT001 (JT-001) is a potent, highly specific NLRP3 inhibitor, inhibits NLRP3 inflammasome assembly.
JT001 potently and selectively inhibited NLRP3 inflammasome assembly, resulting in the inhibition of cytokine release and the prevention of pyroptosis, a form of inflammatory cell death triggered by active caspase-1, in cell-based assays.
Orally administered JT001 was effective in reducing hepatic inflammation in three different murine models, including the Nlrp3A350V/+CreT model of Muckle-Wells syndrome (MWS), a diet-induced obesity NASH model, and a choline-deficient diet-induced NASH model.

物理化学性质&存储条件

分子量	246.24
分子式	C7H10N4O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	O=C(N)NS(=O)(C1=C2OCCCN2N=C1)=O

参考文献

1. Povero D, et al. J Pharmacol Exp Ther. 2023 Aug;386(2):242-258.

JT001 (JT-001)

生物&药学活性

物理化学性质&存储条件

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JT001 (JT-001)

生物&药学活性

物理化学性质&存储条件

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