JNJ-5207852 | Histamine H3 antagonist | Probechem Biochemicals

Chemical Structure : JNJ-5207852

CAS No.: 98473-34-2

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JNJ-5207852 (JNJ5207852)

货号: PC-35408Not For Human Use, Lab Use Only.

JNJ-5207852 (JNJ5207852) is a potent, selective antagonist of H3 receptor with pKi of 8.9 and 9.24 for rat and human H3, respectively.

规格	价格	库存
5 mg	￥980	In stock
10 mg	￥1480	In stock
25 mg	￥2580	In stock
50 mg	￥4280	In stock
100 mg		Get quote

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生物&药学活性

JNJ-5207852 (JNJ5207852) is a potent, selective antagonist of H3 receptor with pKi of 8.9 and 9.24 for rat and human H3, respectively.
JNJ-5207852 does not bind to human H1, H2 or H4 histamine receptors (pKi <5), as well as 50 GPCRs, ion channels and other drug targets.
JNJ-5207852 increases time spent awake and decreases REM sleep and slow-wave sleep in mice and rats (1-10 mg kg(-1) s.c.), ameliorates PTZ kindling-induced learning and mnemonic deficits in weanling mice.

物理化学性质&存储条件

分子量	316.489
分子式	C20H32N2O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(4-(3-(piperidin-1-yl)propoxy)benzyl)piperidine

参考文献

1. Apodaca R, et al. J Med Chem. 2003 Aug 28;46(18):3938-44.

2. Barbier AJ, et al. Br J Pharmacol. 2004 Nov;143(5):649-61.

3. Jia F, et al. Neuropharmacology. 2006 Mar;50(4):404-11.

4. Abuhamdah RM, et al. Front Syst Neurosci. 2012 Jul 16;6:54.

JNJ-5207852 (JNJ5207852)

生物&药学活性

物理化学性质&存储条件

参考文献

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JNJ-5207852 (JNJ5207852)

生物&药学活性

物理化学性质&存储条件

参考文献

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