JNJ-39220675 | Histamine H3 antagonist | Probechem Biochemicals

Chemical Structure : JNJ-39220675

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JNJ-39220675 (JNJ39220675, JNJ 39220675)

货号: PC-61661Not For Human Use, Lab Use Only.

JNJ-39220675 is potent and selective, brain penetrant H3 antagonist with Ki of 1.4 nM, pA2 of 9.42 for hH3.

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生物&药学活性

JNJ-39220675 is potent and selective, brain penetrant H3 antagonist with Ki of 1.4 nM, pA2 of 9.42 for hH3.
JNJ-39220675 dose-dependently reduces both alcohol intake and preference in alcohol-preferring rats.
JNJ-39220675 reduces alcohol self-administration without changing saccharin self-administration in alcohol non-dependent rats.

物理化学性质&存储条件

分子量	369.44
分子式	C21H24FN3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(4-cyclobutyl-1,4-diazepan-1-yl)(6-(4-fluorophenoxy)pyridin-3-yl)methanone

参考文献

1. Letavic MA, et al. Bioorg Med Chem Lett. 2010 Jul 15;20(14):4210-4.

2. Galici R, et al. Psychopharmacology (Berl). 2011 Apr;214(4):829-41.

3. Nuutinen S, et al. Neuropharmacology. 2016 Jul;106:156-63.

4. Vanhanen J, et al. Br J Pharmacol. 2013 Sep;170(1):177-87.

JNJ-39220675 (JNJ39220675, JNJ 39220675)

生物&药学活性

物理化学性质&存储条件

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JNJ-39220675 (JNJ39220675, JNJ 39220675)

生物&药学活性

物理化学性质&存储条件

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