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首页-小分子抑制剂&激动剂-GPCR-Histamine Receptor-JNJ-28307474
JNJ-28307474

Chemical Structure : JNJ-28307474

CAS No.: 848849-40-1

JNJ-28307474 (JNJ 28307474, JNJ28307474)

货号: PC-63410Not For Human Use, Lab Use Only.

JNJ-28307474 is a potent, selective antagonist of the histamine H4 receptor (H4R), inhibits LPS-induced TNF production.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    JNJ-28307474 is a potent, selective antagonist of the histamine H4 receptor (H4R), inhibits LPS-induced TNF production.

    物理化学性质&存储条件

    分子量 410.537
    分子式 C24H31FN4O
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    5-fluoro-4-methyl-2-(5-methyl-2-(4-(1-methylpiperidin-4-yl)butoxy)pyridin-4-yl)-1H-benzo[d]imidazole

    参考文献

    1. Cowden JM, et al. Inflamm Res. 2013 Jun;62(6):599-607.

    2. Cowden JM, et al. Ann Rheum Dis. 2014 Mar;73(3):600-8.

    3. Dib K, et al. J Leukoc Biol. 2014 Sep;96(3):411-8.

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