JNJ-10181457 dihydrochloride | Histamine H3 antagonist

Chemical Structure : JNJ-10181457 dihydrochloride

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JNJ-10181457 dihydrochloride (JNJ 10181457 )

货号: PC-61663Not For Human Use, Lab Use Only.

JNJ-10181457 dihydrochloride is a neutral, potent and selective, brain penetrant H3 antagonist with pKi of 8.93, pA2 of 9.22 for hH3.

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生物&药学活性

JNJ-10181457 dihydrochloride is a neutral, potent and selective, brain penetrant H3 antagonist with pKi of 8.93, pA2 of 9.22 for hH3.
JNJ-10181457 promotes wakefulnessm, but does not increase locomotor activity or produce any alteration of the EEG power spectral activity in rats.
JNJ-10181457 increases extracellular acetylcholine and norepinephrine but not dopamine in rat frontal cortex and shows efficacy in various models of learning-memory deficit.

物理化学性质&存储条件

分子量	385.37
分子式	C20H28N2O.2HCl
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(3-(4-(Piperidinyl)but-1-ynyl)benzyl)morpholine dihydrochloride

参考文献

1. Bonaventure P, et al. Biochem Pharmacol. 2007 Apr 15;73(8):1084-96.

2. Galici R, et al. Neuropharmacology. 2009 Jun;56(8):1131-7.

3. Vanhanen J, et al. Br J Pharmacol. 2013 Sep;170(1):177-87.

JNJ-10181457 dihydrochloride (JNJ 10181457 )

生物&药学活性

物理化学性质&存储条件

参考文献

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JNJ-10181457 dihydrochloride (JNJ 10181457 )

生物&药学活性

物理化学性质&存储条件

参考文献

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