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首页-小分子抑制剂&激动剂-GPCR-Histamine Receptor-JNJ-10181457
JNJ-10181457

Chemical Structure : JNJ-10181457

CAS No.: 544707-19-9

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JNJ-10181457 (JNJ10181457, JNJ 10181457)

货号: PC-61662Not For Human Use, Lab Use Only.

JNJ-10181457 is a neutral, potent and selective, brain penetrant H3 antagonist with pKi of 8.93, pA2 of 9.22 for hH3.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    JNJ-10181457 is a neutral, potent and selective, brain penetrant H3 antagonist with pKi of 8.93, pA2 of 9.22 for hH3.
    JNJ-10181457 promotes wakefulnessm, but does not increase locomotor activity or produce any alteration of the EEG power spectral activity in rats.
    JNJ-10181457 increases extracellular acetylcholine and norepinephrine but not dopamine in rat frontal cortex and shows efficacy in various models of learning-memory deficit.

    物理化学性质&存储条件

    分子量 312.45
    分子式 C20H28N2O
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    4-(3-(4-(Piperidinyl)but-1-ynyl)benzyl)morpholine

    参考文献

    1. Bonaventure P, et al. Biochem Pharmacol. 2007 Apr 15;73(8):1084-96.

    2. Galici R, et al. Neuropharmacology. 2009 Jun;56(8):1131-7.

    3. Vanhanen J, et al. Br J Pharmacol. 2013 Sep;170(1):177-87.

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