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首页-小分子抑制剂&激动剂-GPCR-mAChR-JHU37152
JHU37152

Chemical Structure : JHU37152

CAS No.: 2369979-67-7

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JHU37152 (JHU 37152)

货号: PC-73158Not For Human Use, Lab Use Only.

JHU37152 is a high affinity and highly potent activator (agonist) of hM3Dq and hM4Di DREADDs with Ki 1.8 nM and 8.7 nM for hM3Dq and hM4Di in vitro.

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50 mg ￥880 In stock
100 mg ￥1280 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

JHU37152 is a high affinity, highly potent, BBB penetrant activator (agonist) of hM3Dq and hM4Di DREADDs with Ki 1.8 nM and 8.7 nM for hM3Dq and hM4Di in vitro.
JHU37152 selectively displaces [3H]clozapine from DREADDs in vivo, but not from other clozapine binding sites.
JHU37152 inhibits locomotor activity in mice expressing hM3Dq and hM4Di in D1-expressing neurons.
Designer receptors exclusively activated by designer drugs (DREADD) technology is a powerful chemogenetic approach used for neuromodulation in uninstrumented research animals.

物理化学性质&存储条件

分子量 358.85
分子式 C19H20ClFN4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

8-Chloro-11-(4-ethylpiperazin-1-yl)-1-fluoro-5H-dibenzo[b,e][1,4]diazepine

参考文献

1. Jordi Bonaventura, et al. Nat Commun. 2019 Oct 11;10(1):4627.

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