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首页-小分子抑制剂&激动剂-Others-Other Targets-JHU37152
JHU37152

Chemical Structure : JHU37152

CAS No.: 2369979-67-7

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JHU37152 (JHU 37152)

货号: PC-73158Not For Human Use, Lab Use Only.

JHU37152 is a high affinity and highly potent activator (agonist) of hM3Dq and hM4Di DREADDs with Ki 1.8 nM and 8.7 nM for hM3Dq and hM4Di in vitro.

规格 价格 库存 数量
25 mg ￥2580 In stock
50 mg ￥4280 In stock
100 mg ￥7280 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

JHU37152 is a high affinity, highly potent, BBB penetrant activator (agonist) of hM3Dq and hM4Di DREADDs with Ki 1.8 nM and 8.7 nM for hM3Dq and hM4Di in vitro.
JHU37152 selectively displaces [3H]clozapine from DREADDs in vivo, but not from other clozapine binding sites.
JHU37152 inhibits locomotor activity in mice expressing hM3Dq and hM4Di in D1-expressing neurons.
Designer receptors exclusively activated by designer drugs (DREADD) technology is a powerful chemogenetic approach used for neuromodulation in uninstrumented research animals.

物理化学性质&存储条件

分子量 358.85
分子式 C19H20ClFN4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 Month
Shipping
Solubility

Chemical Name/SMILES

参考文献

1. Jordi Bonaventura, et al. Nat Commun. 2019 Oct 11;10(1):4627.

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