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首页-小分子抑制剂&激动剂-Immunology/Inflammation-NOD-like Receptor (NLR)-JC2-11
JC2-11

Chemical Structure : JC2-11

CAS No.: 937820-89-8

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JC2-11 (J2-11)

货号: PC-20225Not For Human Use, Lab Use Only.

JC2-11 is an anti-inflammasome compound and a pan-inhibitor of the NLRP3, NLRC4, and AIM2 inflammasomes.

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5 mg ￥980 In stock
10 mg ￥1480 In stock
25 mg ￥2580 In stock
50 mg ￥4280 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

JC2-11 is an anti-inflammasome compound and a pan-inhibitor of the NLRP3, NLRC4, and AIM2 inflammasomes.
JC2-11 inhibits NLRP3 inflammasome activation in priming murine bone marrow-derived macrophages (BMDMs), attenuates the secretion of the cleaved caspase-1 (p20) and the release of IL-1β from the NG or MSU-treated cells.
JC2-11 attenuatesNLRC4 and AIM2 inflammasome activation.
JC2-11 attenuates IL-1β and LDH secretion elicited by ATP, flagellin, and dsDNA in BMDMs.
JC2-11 significantly inhibits the release of caspase-1 (p20) and IL-1β from the LPS transfected cells, inhibits IL-1β secretion in cells and mice.
JC2-11 inhibits the inflammasome activation in PMA-treated THP-1 cells.
JC2-11 inhibits the inflammasome activation by disrupting mitochondrial ROS production and caspase-1 activity.
JC2-11 regulates the inflammasome activation by inhibiting several intracellular signals, such as the priming step, mitochondrial ROS production, and caspase-1 activity.

物理化学性质&存储条件

分子量 302.30
分子式 C17H15FO4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(E)-1-(3-fluoro-4-methoxyphenyl)-3-(4-hydroxy-3-methoxyphenyl)prop-2-en-1-one

参考文献

1. Lee G, et al. Sci Rep. 2022 Dec 28;12(1):22484.

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