JC-229 | TbRPA1 inhibitor | Probechem Biochemicals

Chemical Structure : JC-229

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JC-229 (JC229)

货号: PC-20941Not For Human Use, Lab Use Only.

JC-229 is a small-molecule inhibitor that selectively blocks DNA-binding by Trypanosoma brucei replication protein A1 (TbRPA1), exhibits growth inhibition of T. brucei with EC50 of 6.6 uM.

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生物&药学活性

JC-229 is a small-molecule inhibitor that selectively blocks DNA-binding by Trypanosoma brucei replication protein A1 (TbRPA1), exhibits growth inhibition of T. brucei with EC50 of 6.6 uM.
JC-229 (10 uM) resembles TbRPA1 depletion and has higher toxicity against T. brucei than to human cells.
JC-229 exhibited EC50 values of 6.5 µM, 18.4 µM, and 32.1 µM for T. brucei, HEK293, and HeLa, respectively.
JC-229 specifically inhibits the ssDNA-binding activity of TbRPA, strongly inhibited the binding activity of TbDBD-AB and the TbRPA complex with IC50 of 228 and 24.5 nM.

物理化学性质&存储条件

分子量	504.20
分子式	C20H14Cl4N2O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	O=C(NC1=CC=C(Cl)C(Cl)=C1)C2=CC=C(C)C(S(=O)(NC3=CC=C(Cl)C(Cl)=C3)=O)=C2

参考文献

1. Mukherjee A, et al. Nat Commun. 2023 Jul 20;14(1):4390.

JC-229 (JC229)

生物&药学活性

物理化学性质&存储条件

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JC-229 (JC229)

生物&药学活性

物理化学性质&存储条件

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