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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Parasite-Ivermectin
Ivermectin

Chemical Structure : Ivermectin

CAS No.: 70288-86-7

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Ivermectin (MK-933, CD-5024)

货号: PC-24812Not For Human Use, Lab Use Only.

Ivermectin (MK-933) is a broad-spectrum anti-parasite agent, is a specific inhibitor ofimportin α/β-mediated nuclear import with potent antiviral activity towards both HIV-1 and DENV, also is a positive allosteric effector of P2X4 and α7 neuronal nicotinic acetylcholine receptor (nAChRs), also inhibits bovine herpesvirus1 (BoHV-1) replication and inhibits BoHV-1 DNA polymerase nuclear import.

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1 g ￥580 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Ivermectin (MK-933) is a broad-spectrum anti-parasite agent, is a specific inhibitor ofimportin α/β-mediated nuclear import with potent antiviral activity towards both HIV-1 and DENV, also is a positive allosteric effector of P2X4 and α7 neuronal nicotinic acetylcholine receptor (nAChRs), also inhibits bovine herpesvirus1 (BoHV-1) replication and inhibits BoHV-1 DNA polymerase nuclear import.

物理化学性质&存储条件

分子量 875.09
分子式 C48H74O14
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

参考文献

1. Khakh BS, et al. J Neurosci. 1999 Sep 1;19(17):7289-99.

2. Wagstaff KM, et al. Biochem J. 2012 May 1;443(3):851-6.

3. Raza S, et al. Microorganisms. 2020 Mar 13;8(3). pii: E409.

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