Irdabisant (CEP-26401) | H3 receptor antagonist | Probechem Biochemicals

Chemical Structure : Irdabisant

CAS No.: 1005402-19-6

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Irdabisant (CEP-26401, CEP26401)

货号: PC-61615Not For Human Use, Lab Use Only.

Irdabisant (CEP-26401) is a potent, selective, orally active histamine H3 receptor antagonist with Ki of 2 nM and 7 nM for human and rat H3Rs, respectivity.

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5 mg	￥2280	In stock
10 mg	￥3680	In stock
25 mg	￥5680	In stock
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生物&药学活性

Irdabisant (CEP-26401) is a potent, selective, orally active histamine H3 receptor antagonist with Ki of 2 nM and 7 nM for human and rat H3Rs, respectivity.
Irdabisant (CEP-26401) displays >1,000-fold selectivity over the H1R, H2R, and hH4R subtypes.
Irdabisant (CEP-26401) dose-dependently inhibits H3R agonist-induced dipsogenia in the rat (ED50=0.06 mg/kg po).
vexhibits cognition-enhancing and wake-promoting activities in mice.

物理化学性质&存储条件

分子量	313.401
分子式	C18H23N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-[4-[3-[(2R)-2-methylpyrrolidin-1-yl]propoxy]phenyl]-1H-pyridazin-6-one

参考文献

1. Hudkins RL, et al. J Med Chem. 2011 Jul 14;54(13):4781-92.

2. Raddatz R, et al. J Pharmacol Exp Ther. 2012 Jan;340(1):124-33.

3. Spiegelstein O, et al. J Psychopharmacol. 2016 Oct;30(10):983-93.

Irdabisant (CEP-26401, CEP26401)

生物&药学活性

物理化学性质&存储条件

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Irdabisant (CEP-26401, CEP26401)

生物&药学活性

物理化学性质&存储条件

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