IPAG | Sigma 1 inhibitor | Probechem Biochemicals

Chemical Structure : IPAG

CAS No.: 193527-91-2

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IPAG (Sigma 1 inhibitor)

货号: PC-60076Not For Human Use, Lab Use Only.

IPAG is a prototypic selective inhibitor of sigma1 receptor that engages the unfolded protein response and induces autophagy in cancer cells.

规格	价格	库存
5 mg	￥880	In stock
10 mg	￥1280	In stock
25 mg	￥2180	In stock
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100 mg		Get quote

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生物&药学活性

IPAG is a prototypic selective inhibitor of sigma1 receptor that engages the unfolded protein response and induces autophagy in cancer cells.
IPAG induces autophagic degradation of PD-L1 in PC3 and MDA-MB-231 cells.

物理化学性质&存储条件

分子量	395.29
分子式	C17H22IN3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	50 mM in ethanol;100 mM in DMSO
Chemical Name/SMILES	1-(4-Iodophenyl)-3-(2-adamantyl)guanidine

参考文献

1. Wilson AA, et al. J Med Chem. 1991 Jun;34(6):1867-70.

2. Whittemore ER, et al. J Pharmacol Exp Ther. 1997 Jul;282(1):326-38.

3. Schrock JM, et al. Mol Pharmacol. 2013 Nov;84(5):751-62.

4. Maher CM, et al. Mol Cancer Res. 2017 Nov 8. pii: molcanres.0166.2017.

IPAG (Sigma 1 inhibitor)

生物&药学活性

物理化学性质&存储条件

参考文献

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IPAG (Sigma 1 inhibitor)

生物&药学活性

物理化学性质&存储条件

参考文献

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