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首页-小分子抑制剂&激动剂-Immunology/Inflammation-NOD-like Receptor (NLR)-INF200
INF200

Chemical Structure : INF200

CAS No.:

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INF200 (INF 200, INF-200)

货号: PC-22764Not For Human Use, Lab Use Only.

INF200 is a novel sulfonylurea-based NLRP3 inhibitor, specifically inhibits NLRP3-driven pyroptosis with IC50 of 1.55 uM, efficiently reduces cardiac and metabolic complications in in vivo model of diet-induced metaflammation.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

INF200 is a novel sulfonylurea-based NLRP3 inhibitor, specifically inhibits NLRP3-driven pyroptosis with IC50 of 1.55 uM, efficiently reduces cardiac and metabolic complications in in vivo model of diet-induced metaflammation. IFN200 reduced IRI-dependent NLRP3 activation, inflammation, and oxidative stress.

物理化学性质&存储条件

分子量 296.71
分子式 C13H13ClN2O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

ethyl 2-(5-(2-chlorobenzyl)-2-oxo-1,3,4-oxadiazol-3(2H)-yl)acetate

参考文献

1. Simone Gastaldi, et al. Eur J Med Chem. 2023 Sep 5:257:115542.

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