IC261 (SU-5607) | CK1δ/CK1ε inhibitor | Probechem Biochemicals

Chemical Structure : IC261

CAS No.: 186611-52-9

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IC261 (IC-261, SU-5607)

货号: PC-43200Not For Human Use, Lab Use Only.

IC261 (IC-261, SU-5607) is a potent, specific, ATP-competitive CK1delta/epsilon (CK1δ/CK1ε) with IC50 of 1 uM, does not block the activity of α, β and γ isoforms.

规格	价格	库存
5 mg	￥780	In stock
10 mg	￥1180	In stock
25 mg	￥1880	In stock
50 mg	￥2980	In stock
100 mg		Get quote

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生物&药学活性

IC261 (IC-261, SU-5607) is a potent, specific, ATP-competitive CK1delta/epsilon (CK1δ/CK1ε) with IC50 of 1 uM, does not block the activity of α, β and γ isoforms.
IC261 specifically blocks phosphorylation in vivo of the CK1delta/epsilon phosphorylation sites in p53 in murine SV3T3 cells, inhibits cytokinesis causing a transient mitotic arrest.
IC261 reduces pancreatic tumour cell growth in vitro and in vivo, decreases the expression levels of several anti-apoptotic proteins and sensitises cells to CD95-mediated apoptosis.

物理化学性质&存储条件

分子量	311.3319
分子式	C18H17NO4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 33 mg/mL
Chemical Name/SMILES	2H-Indol-2-one, 1,3-dihydro-3-[(2,4,6-trimethoxyphenyl)methylene]-

参考文献

1. Knippschild U, et al. Oncogene. 1997 Oct 2;15(14):1727-36.

2. Behrend L, et al. Oncogene. 2000 Nov 9;19(47):5303-13.

3. Mashhoon N, et al. J Biol Chem. 2000 Jun 30;275(26):20052-60.

4. Brockschmidt C, et al. Gut. 2008 Jun;57(6):799-806.

IC261 (IC-261, SU-5607)

生物&药学活性

物理化学性质&存储条件

参考文献

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IC261 (IC-261, SU-5607)

生物&药学活性

物理化学性质&存储条件

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