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Herboxidiene

Chemical Structure : Herboxidiene

CAS No.: 142861-00-5

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Herboxidiene (GEX1A, TAN-1609)

货号: PC-62862Not For Human Use, Lab Use Only.

Herboxidiene (GEX1A, TAN-1609) is a polyketide molecule first isolated from the fermentation broth of Streptomyces chromofuscus, shows in vitro antitumor activity by targeting the SF3B protein in the splicesosome.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    Herboxidiene (GEX1A, TAN-1609) is a polyketide molecule first isolated from the fermentation broth of Streptomyces chromofuscus, shows in vitro antitumor activity by targeting the SF3B protein in the splicesosome.
    Herboxidiene  inhibits the pre-mRNA splicing of p27, targets SAP155 protein, a subunit of SF3b responsible for pre-mRNA splicing.

    物理化学性质&存储条件

    分子量 438.61
    分子式 C25H42O6
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-((2R,5S,6S)-6-((2E,4E,6S)-7-((1R,2R)-2-((3R,4R)-4-hydroxy-3-methoxypentan-2-yl)-1-methylcyclopropyl)-6-methylhepta-2,4-dien-2-yl)-5-methyltetrahydro-2H-pyran-2-yl)acetic acid

    参考文献

    1. Ghosh AK, et al. Org Biomol Chem. 2016 Jun 21;14(23):5263-71.

    2. AlShareef S, et al. BMC Genomics. 2017 Mar 27;18(1):260.

    3. Hasegawa M, et al. ACS Chem Biol. 2011 Mar 18;6(3):229-33.

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