HS220 | PfPK9 inhibitor | Probechem Biochemicals

Chemical Structure : HS220

CAS No.: 1570374-32-1

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HS220 (HS-220, HS 220)

货号: PC-35930Not For Human Use, Lab Use Only.

HS220 (HS-220) is a Plasmodium-selective takinib analog that targets atypical P. falciparum protein kinase 9 (PfPK9, Kd=4.1 uM) but does not inhibit HsTAK1, decreases K63-linked ubiquitination in P. falciparum.

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10 mg	￥2980	In stock
25 mg	￥4980	In stock
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生物&药学活性

HS220 (HS-220) is a Plasmodium-selective takinib analog that targets atypical P. falciparum protein kinase 9 (PfPK9, Kd=4.1 uM) but does not inhibit HsTAK1, decreases K63-linked ubiquitination in P. falciparum.
HS220 inhibits P. berghei parasite load in HuH7 cells with EC50 of 43 uM, with no significant change on HuH7 viability.
HS220 induce a unique phenotype where parasite size in hepatocytes increases.

物理化学性质&存储条件

分子量	323.352
分子式	C18H17N3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-((1-propyl-1H-benzo[d]imidazol-2-yl)carbamoyl)benzoic acid

参考文献

1. Raphemot R, et al. Cell Chem Biol. 2018 Nov 19. pii: S2451-9456(18)30391-X.

HS220 (HS-220, HS 220)

生物&药学活性

物理化学性质&存储条件

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HS220 (HS-220, HS 220)

生物&药学活性

物理化学性质&存储条件

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