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首页-抗体药物偶连体和PROTACs-PROTAC-HLB-0532259
HLB-0532259

Chemical Structure : HLB-0532259

CAS No.: 2566733-45-5

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HLB-0532259 (HLB0532259)

货号: PC-23772Not For Human Use, Lab Use Only.

HLB-0532259 is a potent, selective Aurora-A PROTAC degrader with DC50 of 20.2 nM in non-MYCN amplified MCF-7 cells.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    HLB-0532259 is a potent, selective Aurora-A PROTAC degrader with DC50 of 20.2 nM in non-MYCN amplified MCF-7 cells.
    HLB-0532259 degrades N-Myc in MYCN amplified cells SK-N-BE and Kelly with DC50 of 179 nM and 229 nM, respectively.
    HLB-0532259 promotes the degradation of Aurora-A, which elicits concomitant N-Myc degradation, with nanomolar potency and excellent selectivity.

    物理化学性质&存储条件

    分子量 748.84
    分子式 C40H44N8O7
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    7-cyclopentyl-2-((4-((6-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)hexyl)carbamoyl)phenyl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide

    参考文献

    1. Tang J, et al. Cell Chem Biol. 2025 Jan 6:S2451-9456(24)00516-6.

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