HDAC8 PROTAC 1 | HDAC8 degrader | Probechem Biochemicals

Chemical Structure : HDAC8 PROTAC 1

CAS No.:

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HDAC8 PROTAC 1 (HDAC8 PROTAC 4c)

货号: PC-73287Not For Human Use, Lab Use Only.

HDAC8 PROTAC 1 is a first-in-class proteolysis targeting chimera (PROTAC) for selective degradation of histone deacetylase 8 (HDAC8) with DC50 of 0.7 uM in T-cell leukemia Jurkat cells.

规格	价格	库存
2 mg	￥2580	In stock
10 mg	￥3980	In stock
25 mg	￥5980	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

HDAC8 PROTAC 1 is a first-in-class proteolysis targeting chimera (PROTAC) for selective degradation of histone deacetylase 8 (HDAC8) with DC50 of 0.7 uM in T-cell leukemia Jurkat cells.
HDAC8 PROTAC 1 does not influence the levels of HDAC1, HDAC2, and HDAC6.
HDAC8 PROTAC 1 strongly inhibits Jurkat cell growth with a GI50 value of 0.78 μM
HDAC8 PROTAC 1 induced degradation of HDAC8 without affecting the levels of other HDACs in cellular assays, and inhibited the growth of T-cell leukemia Jurkat cells more potently than a conventional HDAC8 inhibitor.
HDAC8 PROTAC 1 degrades HDAC8 via PROTAC-mediated UPS

物理化学性质&存储条件

分子量	794.928
分子式	C41H46N8O7S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(11-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)undecyl)-3-(((1-(3-(hydroxycarbamoyl)phenyl)-1H-1,2,3-triazol-4-yl)methyl)thio)benzamide

参考文献

1. Jiranan Chotitumnavee, et al. Chem Commun (Camb). 2022 Apr 7;58(29):4635-4638.

HDAC8 PROTAC 1 (HDAC8 PROTAC 4c)

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HDAC8 PROTAC 1 (HDAC8 PROTAC 4c)

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物理化学性质&存储条件

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