HDAC6 PROTAC A6

Chemical Structure : HDAC6 PROTAC A6

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货号: PC-23854Not For Human Use, Lab Use Only.

HDAC6 PROTAC A6 is a potent, selective HDAC6 PROTAC degrader with DC50 of 3.5 nM, Dmax values of over 80% in HL-60 cells.

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生物&药学活性

HDAC6 PROTAC A6 is a potent, selective HDAC6 PROTAC degrader with DC50 of 3.5 nM, Dmax values of over 80% in HL-60 cells.
HDAC6 PROTAC A6 induces dose-dependent α-tubulin hyperacetylation with an EC50 of 0.4 μM in HL-60 cells.
does not affect other HDAC related proteins (HDAC1–11, SIRT1–7, and HDRP), HDAC1/2/3/6/7/10 and SIRT1/2/3/5/6.
HDAC6 PROTAC A6 induces the degradation of HDAC6 occurs via the ternary complex formation and ubiquitin–proteasome pathway.
HDAC6 PROTAC A6 inhibits cell viability of leukemia cell lines with double-digit micromolar potency, also induces apoptosis of MOLM13 cells in a caspase 3/7-dependent fashion through arresting the cells in sub-G1 phase.

物理化学性质&存储条件

分子量	734.81
分子式	C37H46N6O10
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(8-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)octanamido)-N-(7-(hydroxyamino)-7-oxoheptyl)benzamide

参考文献

1. Sinatra L, et al. J Med Chem. 2022 Dec 22;65(24):16860-16878.

HDAC6 PROTAC A6

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HDAC6 PROTAC A6

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