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首页-小分子抑制剂&激动剂-Immunology/Inflammation-STING-HB3089
HB3089

Chemical Structure : HB3089

CAS No.: 2630929-72-3

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HB3089 (HB 3089)

货号: PC-49595Not For Human Use, Lab Use Only.

HB3089 (HB-3089) is a novel potent, highly specific STING agonist, dose-dependently activates interferon-stimulated gene (ISG) signaling in THP1-Dual reporter cells with EC50 of 1-10 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    HB3089 (HB-3089) is a novel potent, highly specific STING agonist, dose-dependently activates interferon-stimulated gene (ISG) signaling in THP1-Dual reporter cells with EC50 of 1-10 uM.
    HB3089 showed comparable ability to diABZI in increasing the thermal stability of various human STING isoforms and mouse STING.
    HB3089 treatment (1 uM) activated the STING downstream TBK1/IRF3 signaling in dose-dependent and time-dependent manners.
    HB3089 also showed the wide activation on two major human STING isoforms, STING-R232 and STING-H232.
    HB3089 induced conformational changes of ligand-binding domain of STING.
    HB3089 exhibited higher anti-tumor activity than STING agonist diABZI compound 3 (Cat# PC-35785) in 4T1 breast cancer and U14 cervical cancer, significantly increased CD86+ macrophages after 72 h treatment on peripheral and tumor-infiltrated immune cells from 4T1 allograft tumors.

    物理化学性质&存储条件

    分子量 873.976
    分子式 C44H51N13O7
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (E)-1-(4-(5-carbamoyl-2-(1-ethyl-3-methyl-1H-pyrazole-5-carboxamido)-7-(3-morpholinopropoxy)-1H-benzo[d]imidazol-1-yl)but-2-en-1-yl)-2-(1-ethyl-3-methyl-1H-pyrazole-5-carboxamido)-7-methyl-1H-benzofuro[4,5-d]imidazole-5-carboxamide

    参考文献

    1. Zuoquan Xie, et al. Cell Discov. 2022 Dec 13;8(1):133.

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