Gambogic amide | TrkA agonist | Probechem Biochemicals

Chemical Structure : Gambogic amide

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Gambogic amide (TrkA agonist)

货号: PC-70266Not For Human Use, Lab Use Only.

Gambogic amide is a potent, selective high affinity TrkA receptor agonist with Kd of 75 nM.

规格	价格	库存	数量
5 mg		Get quote
10 mg		Get quote
25 mg		Get quote

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生物&药学活性

Gambogic amide is a potent, selective high affinity TrkA receptor agonist with Kd of 75 nM.
Gambogic amide selectively binds to TrkA, but not TrkB or TrkC, and robustly induces its tyrosine phosphorylation and downstream signaling activation, including Akt and MAPKs.
Gambogic amide potently represses cyclin A1 expression and blocks K562 cell proliferation.
Gambogic amide diminishes kainic acid-triggered neuronal cell death and decreases infarct volume in the transient middle cerebral artery occlusion model of stroke in mice.

物理化学性质&存储条件

分子量	627.778
分子式	C38H45NO7
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(Z)-4-((1S,3aR,5S,11R,14aS)-8-hydroxy-2,2,11-trimethyl-13-(3-methylbut-2-en-1-yl)-11-(4-methylpent-3-en-1-yl)-4,7-dioxo-1,2,5,7-tetrahydro-11H-1,5-methanofuro[3,2-g]pyrano[3,2-b]xanthen-3a(4H)-yl)-2-methylbut-2-enamide

参考文献

1. Jang SW, et al. Proc Natl Acad Sci U S A. 2007 Oct 9;104(41):16329-34.

2. Chan CB, et al. Oncogene. 2009 Oct 29;28(43):3825-36.

3. Obianyo O, et al. Biochim Biophys Acta. 2013 Oct;1834(10):2213-8.