GZ389988 | TrkA inhibitor | Probechem Biochemicals

Chemical Structure : GZ389988

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GZ389988 (GZ-389988, GZ 389988)

货号: PC-35954Not For Human Use, Lab Use Only.

GZ389988 (GZ-389988) is a novel potent, selective, locally delivered TrkA inhibitor for the treatment osteoarthritis.

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生物&药学活性

GZ389988 (GZ-389988) is a novel potent, selective, locally delivered TrkA inhibitor for the treatment osteoarthritis.
GZ389988 shows similar IC50 values for TrkA, TrkB and TrkC, and the growth factor receptor cFMS (CSF1R).
GZ389988 is highly selective against a wide panel of other kinases.
GZ389988 can significantly reduces local joint pain, without effect on ipsilateral joint pain.
GZ389988 also is efficacious in the PGPS arthritis model, demonstrating a significant improvement of gait analysis scores following painful disease reactivation flares.

物理化学性质&存储条件

分子量	470.533
分子式	C26H26N6O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(3-methoxy-4-((4-methoxybenzyl)oxy)benzyl)-6-(1-methyl-1H-pyrazol-4-yl)-3H-imidazo[4,5-b]pyridin-2-amine

GZ389988 (GZ-389988, GZ 389988)

生物&药学活性

物理化学性质&存储条件

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GZ389988 (GZ-389988, GZ 389988)

生物&药学活性

物理化学性质&存储条件

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