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GW844520

Chemical Structure : GW844520

CAS No.: 137735-25-2

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GW844520 (GW 844520)

货号: PC-20293Not For Human Use, Lab Use Only.

GW844520 is a potent, selective inhibitor of P. falciparum cytochrome bc1 with IC50 of 2 nM, binds to Qi site of cytochrome bc1 and shows potent antimalarial activity.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    GW844520 is a potent, selective inhibitor of P. falciparum cytochrome bc1 with IC50 of 2 nM, binds to Qi site of cytochrome bc1 and shows potent antimalarial activity.
    GW844520 shows weak inhibition for cytochrome bc1 from HEK293 cells with IC50 of 300 nM (>100-fold selectivity).
    GW844520 displays potent antimalarial activity against Plasmodium falciparumin vitro (P. falciparum 3D7A, IC50=5 nM, whole cell assay).

    物理化学性质&存储条件

    分子量 409.79
    分子式 C20H15ClF3NO3
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    3-chloro-2,6-dimethyl-5-(4-(4-(trifluoromethoxy)phenoxy)phenyl)pyridin-4(1H)-one

    参考文献

    1. Capper MJ, et al. Proc Natl Acad Sci U S A. 2015 Jan 20;112(3):755-60.

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