GW461484A | Yck2 inhibitor | Probechem Biochemicals

Chemical Structure : GW461484A

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GW461484A (GW-461484A)

货号: PC-72423Not For Human Use, Lab Use Only.

GW461484A (GW-461484A) is a potent small molecule capable of restoring caspofungin sensitivity, inhibits Yck2 kinase in C. albicans, originally discovered as an inhibitor of human p38α with IC50 of 150 nM.

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生物&药学活性

GW461484A (GW-461484A) is a potent small molecule capable of restoring caspofungin sensitivity, inhibits Yck2 kinase in C. albicans, originally discovered as an inhibitor of human p38α with IC50 of 150 nM.
GW461484A inhibited a very narrow spectrum of human kinases. At 1 uM, it showed >80% binding to only 10 additional human kinases out of a panel of >400 kinases.
Yck2 is the proximal target of GW responsible for restoration of echinocandin sensitivity in C. albicans, potently inhibits Yck2 kinase activity in vitro and impairs the virulence of C. albicans in co-cultures and in mice.
GW461484A potentiates conventional antifungals against a broad range of pathogens.

物理化学性质&存储条件

分子量	303.34
分子式	C19H14FN3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(4-fluorophenyl)-6-methyl-3-(pyridin-4-yl)pyrazolo[1,5-a]pyridine

参考文献

1. Tavia Caplan, et al. Cell Chem Biol. 2020 Mar 19;27(3):269-282.e5.

2. Cheung M, et al. Bioorg Med Chem Lett. 2008 Oct 15; 18(20):5428-30.

GW461484A (GW-461484A)

生物&药学活性

物理化学性质&存储条件

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GW461484A (GW-461484A)

生物&药学活性

物理化学性质&存储条件

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