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首页-小分子抑制剂&激动剂-Tyrosine Kinase-Trk Receptor-GW441756
GW441756

Chemical Structure : GW441756

CAS No.: 504433-23-2

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GW441756 (GW-441756, GW 441756)

货号: PC-45453Not For Human Use, Lab Use Only.

GW441756 is a potent, specific TrkA inhibitor with IC50 value of 2 nM.

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5 mg (Free Sample) ￥280 In stock
25 mg ￥1280 In stock
50 mg ￥1980 In stock
100 mg ￥3280 In stock
250 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

GW441756 is a potent, specific TrkA inhibitor with IC50 value of 2 nM.
GW441756 shows no significant inhibition on CDK2 and c-Raf1 (IC50> 7 uM).
GW441756 blockes gammaH2AX production and decreases ES cell proliferation.

物理化学性质&存储条件

分子量 275.3046
分子式 C17H13N3O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: < 11.2 mg/mL
Chemical Name/SMILES

2H-Pyrrolo[3,2-b]pyridin-2-one, 1,3-dihydro-3-[(1-methyl-1H-indol-3-yl)methylene]-

参考文献

1. Wood ER, et al. Bioorg Med Chem Lett. 2004 Feb 23;14(4):953-7.

2. Heinen TE, et al. Oncotarget. 2016 Jun 7;7(23):34860-80.

3. Jung EJ, et al. Mol Cells. 2008 Jul 31;26(1):12-7.

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