GSK3186899 | Parasite CRK12 inhibitor | Probechem Biochemicals

Chemical Structure : GSK3186899

CAS No.: 1972617-87-0

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GSK3186899 (GSK-3186899, DDD853651, DDD-853651)

货号: PC-35894Not For Human Use, Lab Use Only.

GSK3186899 (GSK-3186899, DDD853651) is a novel specific inhibitor of parasite cdc-2-related kinase 12 (CRK12), shows activity against L. donovani in intra-macrophage assay with EC50 value of 1.4 uM, and shows good selectivity against mammalian THP-1 host cells (EC50> 50 uM).

规格	价格	库存
5 mg	￥3880	In stock
10 mg	￥5780	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

GSK3186899 (GSK-3186899, DDD853651) is a novel specific inhibitor of parasite cdc-2-related kinase 12 (CRK12), shows activity against L. donovani in intra-macrophage assay with EC50 value of 1.4 uM, and shows good selectivity against mammalian THP-1 host cells (EC50> 50 uM).
GSK3186899 also shows activity against L. donovani axenic amastigotes with EC50 of 17 nM.
GSK3186899 demonstrates efficacy mouse model of visceral leishmaniasis.

物理化学性质&存储条件

分子量	491.534
分子式	C19H28F3N7O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-Propanesulfonamide, 3,3,3-trifluoro-N-[trans-4-[[3-[(2S)-2-methyl-4-morpholinyl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino]cyclohexyl]-

参考文献

1. Wyllie S, et al. Nature. 2018 Aug;560(7717):192-197.

2. Thomas MG, et al. J Med Chem. 2018 Dec 20. doi: 10.1021/acs.jmedchem.8b01218.

3. WIPO patent WO/2016/116563 (2016).

GSK3186899 (GSK-3186899, DDD853651, DDD-853651)

生物&药学活性

物理化学性质&存储条件

参考文献

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GSK3186899 (GSK-3186899, DDD853651, DDD-853651)

生物&药学活性

物理化学性质&存储条件

参考文献

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