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首页-小分子抑制剂&激动剂-GPCR-mAChR-GSK1034702
GSK1034702

Chemical Structure : GSK1034702

CAS No.: 932373-87-0

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GSK1034702 (GSK-1034702;GSK 1034702)

货号: PC-35626Not For Human Use, Lab Use Only.

GSK1034702 (GSK-1034702) is a potent, allosteric M1 receptor agonist, inhibits binding of [3H]-NMS (0.5 nM) to M1 mAChR with pKi of 6.5.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

GSK1034702 (GSK-1034702) is a potent, allosteric M1 receptor agonist, inhibits binding of [3H]-NMS (0.5 nM) to M1 mAChR with pKi of 6.5.
GSK1034702 improves memory encoding potentially by modulating hippocampal function.

物理化学性质&存储条件

分子量 333.407
分子式 C18H24FN3O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

7-fluoro-5-methyl-3-[1-(oxan-4-yl)piperidin-4-yl]-1H-benzimidazol-2-one

参考文献

1. Nathan PJ, et al. Int J Neuropsychopharmacol. 2013 May;16(4):721-31.

2. Bradley SJ, et al. Mol Pharmacol. 2018 Jun;93(6):645-656.

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