GNF-6702 |Cas:1799329-72-8 Buy GNF-6702 from ProbeChem, Global Biochemicals Supplier

Chemical Structure : GNF-6702

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GNF-6702 (GNF 6702;GNF6702)

货号: PC-60315Not For Human Use, Lab Use Only.

GNF-6702 (GNF6702) is a selective, non-competitive inhibitor of the kinetoplastid proteasome, inhibits the chymotrypsin-like activity of the T. cruzi proteasome with IC50 of 35 nM.

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生物&药学活性

GNF-6702 (GNF6702) is a selective, non-competitive inhibitor of the kinetoplastid proteasome, inhibits the chymotrypsin-like activity of the T. cruzi proteasome with IC50 of 35 nM; displays no inhibitory effect on caspase-like and the trypsin-like activities (>10 uM); does not inhibit the mammalian proteasome or growth of mammalian cells, and is well-tolerated in mice; clears parasites in mouse models of kinetoplastid infections.

物理化学性质&存储条件

分子量	429.406
分子式	C22H16FN7O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[4-fluoro-3-(6-pyridin-2-yl-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)phenyl]-2,4-dimethyl-1,3-oxazole-5-carboxamide

参考文献

1. Khare S, et al. Nature. 2016 Sep 8;537(7619):229-233.

GNF-6702 (GNF 6702;GNF6702)

生物&药学活性

物理化学性质&存储条件

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GNF-6702 (GNF 6702;GNF6702)

生物&药学活性

物理化学性质&存储条件

参考文献

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