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GNF-2-deg

Chemical Structure : GNF-2-deg

CAS No.:

GNF-2-deg

货号: PC-22559Not For Human Use, Lab Use Only.

GNF-2-deg is a PROTAC targeting the dengue virus (DENV) envelope (E) protein with DC50 of 0.83 uM, Dmax of 99%, depletes intracellular E via a CRBN- and proteasome-dependent mechanism.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

GNF-2-deg is a PROTAC targeting the dengue virus (DENV) envelope (E) protein with DC50 of 0.83 uM, Dmax of 99%, depletes intracellular E via a CRBN- and proteasome-dependent mechanism.
GNF-2-deg exhibits increased antiviral potency compared to the parental E inhibitor GNF-2, with EC90 WT value of 3.5 uM, and 13.11 uM respectively.
GNF-2-deg has a dual mode of action: inhibition of E's function in viral entry and blocking of viral particle production due to a targeted protein degradation (TPD) mechanism.
GNF-2-deg exhibits broad-spectrum activity against multiple flaviviruses, with antiviral EC90 values consistently in the single-digit micromolar across ZIKV, JEV, and WNV Kunjin.

物理化学性质&存储条件

分子量 762.70
分子式 C37H33F3N6O9
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)oxy)ethoxy)ethoxy)ethyl)-3-(6-((4-(trifluoromethoxy)phenyl)amino)pyrimidin-4-yl)benzamide

参考文献

1. Liu HY, et al. Nat Commun. 2024 Jun 19;15(1):5179.

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