GM310 | Sigma-1 agonist | Probechem Biochemicals

Chemical Structure : GM310

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GM310 (GM-310, GM 310)

货号: PC-20968Not For Human Use, Lab Use Only.

GM310 is a small molecule inhibitor of glycolysis, proteotoxicity, inflammation, and impairments in animal models of Alzheime's, Huntington's, and stroke by activation of the Sigma-1 receptor.

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生物&药学活性

GM310 is a small molecule inhibitor of glycolysis, proteotoxicity, inflammation, and impairments in animal models of Alzheime's, Huntington's, and stroke by activation of the Sigma-1 receptor.
GM310 inhibits a wide range of pro-inflammatory cytokines in mouse and human myeloid cells, and delays impairments in animal models of AD, Huntington's, and stroke.
GM310 is highly concentrated in brain after oral delivery with no apparent toxicity, increases lifespan, and produces molecular responses highly similar to those produced by dietary restriction.

物理化学性质&存储条件

分子量	342.48
分子式	C20H23FN2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	CN1C(CCN2C3=C(C=CC=C3)SC4=CC=C(F)C=C24)CCCC1

参考文献

1. Rachel Litke, et al. bioRxiv. 2023 Jun 13;2023.06.12.544352.

GM310 (GM-310, GM 310)

生物&药学活性

物理化学性质&存储条件

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GM310 (GM-310, GM 310)

生物&药学活性

物理化学性质&存储条件

参考文献

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