GB1490 | Galectin-1 inhibitor | Probechem Biochemicals

Chemical Structure : GB1490

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GB1490 (GB 1490, GB-1490)

货号: PC-21528Not For Human Use, Lab Use Only.

GB1490 is a potent, selective and orally available galectin-1 (gal-1) inhibitor with Kd value of 0.4 uM and 0.23 uM for human and mouse galectin-1, respectively.

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生物&药学活性

GB1490 is a potent, selective and orally available galectin-1 (gal-1) inhibitor with Kd value of 0.4 uM and 0.23 uM for human and mouse galectin-1, respectively.
GB1490 displays 25-fold specificity for galectin-1 over galectin-3 in mice.
GB1490 inhibits galectin-1-induced apoptosis of Jurkat cells with an IC50 value of 2.30 uM, but not OTX008.
GB1490 works as a functional tool binding to the CRD of galectin-1 at nM affinity and can in cell systems inhibit galectin-1-driven pharmacology.

物理化学性质&存储条件

分子量	493.35
分子式	C17H15Cl2FN4O4S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3,5-Dichloro-4-fluorophenyl 3-Deoxy-3-[4-(thiazol-2-yl)-1H-1,2,3-triazol-1-yl]-1-thio-alpha-d-galactopyranoside

参考文献

1. Zetterberg FR, et al. J Med Chem. 2023 Dec 7. doi: 10.1021/acs.jmedchem.3c01787.

GB1490 (GB 1490, GB-1490)

生物&药学活性

物理化学性质&存储条件

参考文献

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GB1490 (GB 1490, GB-1490)

生物&药学活性

物理化学性质&存储条件

参考文献

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