Selvigaltin (GB1211) | Galectin-3 inhibitor | Probechem Biochemicals

Chemical Structure : GB1211

CAS No.: 1978336-95-6

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GB1211 (Selvigaltin, GB-1211)

货号: PC-49544Not For Human Use, Lab Use Only.

Selvigaltin (GB1211) is a highly potent, selective and orally active Galectin-3 inhibitor with binding Kd of 25 nM in FP assays.

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2 mg	￥2880	In stock
5 mg	￥4980	In stock
10 mg	￥7880	In stock
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100 mg		Get quote

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生物&药学活性

Selvigaltin (GB1211) is a highly potent, selective and orally active Galectin-3 inhibitor with binding Kd of 25 nM in FP assays.
GB1211 displays >100-fold selectivity over Galectin-1 as well as low CYP P450 inhibition, also shows no affinity against a panel of 87 different targets (enzymes, receptors, and ion channels).
GB1211 inhibits galectin-3 expression in human monocyte THP1 cells with IC50 of 220.3 nM, inhibits TGFβ stimulated pro-fibrotic gene expression in human liver stellate cell line (LX2) in vitro.
GB1211 (2 mg/kg or 10 mg/kg bid, oral) reduces fibrosis in mouse CCl4-induced liver fibrosis model.
GB1211 is currently in clinical development as a novel, orally active therapy for liver fibrosis.

物理化学性质&存储条件

分子量	533.320
分子式	C19H16BrF3N4O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-Bromopyridin-3-yl 3-Deoxy-3-[4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl]-1-thio-alpha-d-galactopyranoside

参考文献

1. Fredrik R Zetterberg, et al. J Med Chem. 2022 Oct 13;65(19):12626-12638.

GB1211 (Selvigaltin, GB-1211)

生物&药学活性

物理化学性质&存储条件

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GB1211 (Selvigaltin, GB-1211)

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物理化学性质&存储条件

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