G6374 | IRE1 PROTAC | Probechem Biochemicals

Chemical Structure : G6374

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G6374 (G-6374)

货号: PC-25906Not For Human Use, Lab Use Only.

G6374 is a selective, effective PROTAC degrader for endogenous IRE1 with DC50 of 0.04 uM and Dmax of 93% in AMO1 multiple myeloma (MM) cells.

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生物&药学活性

G6374 is a selective, effective PROTAC degrader for endogenous IRE1 with DC50 of 0.04 uM and Dmax of 93% in AMO1 multiple myeloma (MM) cells.
G6374 induced effective depletion of IRE1 in KMS27 MM cells, which express similarly high IRE1 levels, with a Dmax of 98% and a DC50 of 0.13 μM.
G6374 promotes stable association between IRE1 and VHL, and drives IRE1 degradation.
G6374 selectively inhibits IRE1-dependent cancer-cell proliferation regardless of the underlying dependency mode.

物理化学性质&存储条件

分子量	883.17
分子式	C47H66N10O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2S,4R)-4-hydroxy-1-((S)-2-(5-(4-((1r,4S)-4-((8-isopropyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)cyclohexyl)piperazin-1-yl)pentanamido)-3,3-dimethylbutanoyl)-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

参考文献

1. Du J, et al. Nat Commun. 2025 Dec 11. doi: 10.1038/s41467-025-66382-8.

G6374 (G-6374)

生物&药学活性

物理化学性质&存储条件

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G6374 (G-6374)

生物&药学活性

物理化学性质&存储条件

参考文献

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