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首页-小分子抑制剂&激动剂-GPCR-Lysophospholipid Receptor-Fingolimod
Fingolimod

Chemical Structure : Fingolimod

CAS No.: 162359-55-9

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Fingolimod (FTY720 free base, FTY-720 free base)

货号: PC-42800Not For Human Use, Lab Use Only.

Fingolimod (FTY720) is an immunomodulatory agent can be phosphorylated by SphK, then functions as a potent agonist of S1P receptors (S1P1/3/4/5) with EC50 of 0.3-5 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Fingolimod (FTY720) is an immunomodulatory agent can be phosphorylated by SphK, then functions as a potent agonist of S1P receptors (S1P1/3/4/5) with EC50 of 0.3-5 nM.
Fingolimod (FTY720) has no affitnity for S1P2; alters lymphocyte trafficking and inhibits lymphocyte recirculation.

物理化学性质&存储条件

分子量 307.4708
分子式 C19H33NO2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1,3-Propanediol, 2-amino-2-[2-(4-octylphenyl)ethyl]-

参考文献

1. Mandala S, et al. Science. 2002 Apr 12;296(5566):346-9.

2. Suzuki S, et al. Transplantation. 1996 Jan 27;61(2):200-5.

3. Billich A, et al. J Biol Chem. 2003 Nov 28;278(48):47408-15.

4. Forrest M, et al. J Pharmacol Exp Ther. 2004 May;309(2):758-68.

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