Fanotaprim (VYR-006) | TgDHFR inhibitor | Probechem Biochemicals

Chemical Structure : Fanotaprim

CAS No.: 2120282-75-7

加入收藏

Fanotaprim (VYR-006, VYR006)

货号: PC-38359Not For Human Use, Lab Use Only.

Fanotaprim (VYR-006) is a potent, selective Toxoplasma gondii DHFR (TgDHFR) inhibitor with IC50 of 1.6 nM, 200-fold selectivity over human DHFR (hDHFR), shows anti-parasiticidal activity in vitro and in vivo.

规格	价格	库存
5 mg	￥1880	In stock
10 mg	￥2980	In stock
25 mg	￥4980	In stock
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

Fanotaprim (VYR-006) is a potent, selective Toxoplasma gondii DHFR (TgDHFR) inhibitor with IC50 of 1.6 nM, 200-fold selectivity over human DHFR (hDHFR), shows anti-parasiticidal activity in vitro and in vivo.
Fanotaprim (VYR-006) demonstrated a parasiticidal EC50 of 13 nM against the type I RH strain of T. gondii.
Fanotaprim (VYR-006) was effective in radical cure of acute infection with the highly virulent type I RH strain in the murine model showed similar potency across multiple parasite lineages in cell-based parasite growth assays.

物理化学性质&存储条件

分子量	378.440
分子式	C19H22N8O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-(4-(3-(2-Methoxypyrimidin-5-yl)phenyl)piperazin-1-yl)pyrimidine-2,4-diamine

参考文献

1. Allen T Hopper, et al. J Med Chem. 2019 Feb 14;62(3):1562-1576.

Fanotaprim (VYR-006, VYR006)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Fanotaprim (VYR-006, VYR006)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.