Fam20C inhibitor 5k

Chemical Structure : Fam20C inhibitor 5k

加入收藏

货号: PC-23588Not For Human Use, Lab Use Only.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

Fam20C inhibitor 5k is a potent small-molecule Fam20C inhibitor with IC50 of 2.1 uM, showspotent anti-proliferative activity against MDA-MB-231 and BT-549 cells with IC50 values of 11.8 uM and 9.7 uM, respectively.
Compound 5k inhibits proliferation and induces apoptosis in TNBC cells.
Compound 5k inhibits the migration of MDA-MB-231 and BT-549 cells, inhibits the expression of epithelial-mesenchymal transition (EMT) markers.
Compound 5k (10-40 mg/kg) suppresses tumor growth in xenograft tumor nude mouse model of MDA-MB-231 cells, with no noticeable adverse effects.

物理化学性质&存储条件

分子量	555.92
分子式	C26H24BrClN4OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-((1-(3-Bromobenzyl)-1H-benzo[d]imidazol-2-yl)thio)-1-(4-(4-chlorophenyl)piperazin-1-yl)ethan-1-one

参考文献

1. Lu Y, et al. Int J Biol Macromol. 2024 Dec 6:138398.