FR901464 | Spliceosome inhibitor | Probechem Biochemicals

Chemical Structure : FR901464

CAS No.: 146478-72-0

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FR901464 (FR-901464)

货号: PC-62420Not For Human Use, Lab Use Only.

FR901464 is a potent antitumor natural product that binds to the splicing factor 3b (SF3b) complex and inhibits pre-mRNA splicing, inhibits cell cycle progression at G1 and G2/M phases.

规格	价格	库存
1 mg	￥3580	In stock
2 mg	￥5580	In stock
5 mg	￥8980	In stock
10 mg		Get quote
25 mg		Get quote

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生物&药学活性

FR901464 is a potent antitumor natural product that binds to the splicing factor 3b (SF3b) complex and inhibits pre-mRNA splicing, inhibits cell cycle progression at G1 and G2/M phases.

物理化学性质&存储条件

分子量	507.616
分子式	C27H41NO8
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-Pentenamide, 4-(acetyloxy)-N-[(2R,3R,5S,6S)-6-[(2E,4E)-5-[(3R,4R,5R,7S)-4,7-dihydroxy-7-methyl-1,6-dioxaspiro[2.5]oct-5-yl]-3-methyl-2,4-pentadienyl]tetrahydro-2,5-dimethyl-2H-pyran-3-yl]-, (2Z,4S)- (9CI)

参考文献

1. Osman S, et al. Chemistry. 2011 Jan 17;17(3):895-904.

2. Albert BJ, et al. Mol Cancer Ther. 2009 Aug;8(8):2308-18.

3. Satoh T, et al. Sci Rep. 2016 Jun 10;6:27829.

FR901464 (FR-901464)

生物&药学活性

物理化学性质&存储条件

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FR901464 (FR-901464)

生物&药学活性

物理化学性质&存储条件

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