FF2049 | HDAC1-3 PROTAC | Probechem Biochemicals

Chemical Structure : FF2049

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FF2049 (FF-2049)

货号: PC-23853Not For Human Use, Lab Use Only.

FF2049 is a first-in-class, selective Fem-1 homologue B (FEM1B)-recruiting HDAC1-3 PROTAC degrader with DC50 value of 257 nM and Dmax of 85% (HDAC1) in MM.1S cells.

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25 mg		Get quote
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100 mg		Get quote

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生物&药学活性

FF2049 is a first-in-class, selective Fem-1 homologue B (FEM1B)-recruiting HDAC1-3 PROTAC degrader with DC50 value of 257 nM and Dmax of 85% (HDAC1) in MM.1S cells.
FF2049 induced strong and selective degradation of HDAC1–3 with no effect on other HDACs.
FF2049 induced degradation via binding to FEM1B and HDAC1 in neddylation-dependent manner.
FF2049 induced a significant increase in early and late apoptotic cells in hematological cancer cell lines MM.1S and MV4–11.

物理化学性质&存储条件

分子量	656.14
分子式	C31H38ClN7O7
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-[2-(2-{7-[2-Chloro-N-(2-cyanoethyl)acetamido]-2,3-dihydro-4H-benzo[b][1,4]oxazin-4-yl}acetamido)acetamido]-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide

参考文献

1. Feller F, et al. J Med Chem. 2025 Jan 13. doi: 10.1021/acs.jmedchem.4c02569.

FF2049 (FF-2049)

生物&药学活性

物理化学性质&存储条件

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FF2049 (FF-2049)

生物&药学活性

物理化学性质&存储条件

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