FAK degrader F2 | FAK degrader | Probechem Biochemicals

Chemical Structure : FAK degrader F2

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FAK degrader F2 (FAK PROTAC F2)

货号: PC-22493Not For Human Use, Lab Use Only.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

FAK PROTAC F2 is a potent, selective FAK CRBN-recruiting PROTAC degrader based on the FAK inhibitor Ifebemtinib (IN10018) with DC50 of 27.72 nM and 60.10 nM for total FAK and phosphorylated FAK in MDA-MB-231 cells.
FAK PROTAC F2 exhibits potent inhibitory activities against 4T1, MDA-MB-231, MDA-MB-468 and MDA-MB-435 cells with IC50 values of 0.73, 1.09, 5.84 and 3.05 μM, respectively.
FAK PROTAC F2 also remarkably reversed the multidrug resistance (MDR) in HCT8/T, A549/T and MCF-7/ADR cells.
FAK PROTAC F2 exerts anti-tumor effects by inhibiting AKT and ERK signaling pathways and affecting EMT (epithelial-mesenchymal transition).
FAK PROTAC F2 reverses the resistance of multidrug-resistant tumor cells to chemotherapy drugs in vitro and in vivo.

物理化学性质&存储条件

分子量	926.93
分子式	C47H46F4N8O8
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(1-((1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-inden-5-yl)piperidin-4-yl)methyl)piperidin-4-yl)-2-fluoro-5-methoxy-4-((4-((2-methyl-3-oxoisoindolin-4-yl)oxy)-5-(trifluoromethyl)pyrimidin-2-yl)amino)benzamide

参考文献

1. Xu MS, et al. Acta Pharmacol Sin. 2024 Jun 6. doi: 10.1038/s41401-024-01312-w.

FAK degrader F2 (FAK PROTAC F2)

生物&药学活性

物理化学性质&存储条件

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FAK degrader F2 (FAK PROTAC F2)

生物&药学活性

物理化学性质&存储条件

参考文献

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