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首页-小分子抑制剂&激动剂-Immunology/Inflammation-STING-Excavatolide B
Excavatolide B

Chemical Structure : Excavatolide B

CAS No.: 205581-10-8

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Excavatolide B (ExcB)

货号: PC-24094Not For Human Use, Lab Use Only.

Excavatolide B (ExcB) is a marine diterpenoid of covalent STING inhibitor, covalently engages STING at its membrane-proximal Cys91, inhibits STING palmitoylation and signaling, inhibits IFN-β levels in culture supernatants of THP1 macrophages with IC50 of 12.1 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

Excavatolide B (ExcB) is a marine diterpenoid of covalent STING inhibitor, covalently engages STING at its membrane-proximal Cys91, inhibits STING palmitoylation and signaling, inhibits IFN-β levels in culture supernatants of THP1 macrophages with IC50 of 12.1 uM.

物理化学性质&存储条件

分子量 592.64
分子式 C30H40O12
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Butanoic acid, (2aS,3Z,6S,7R,7aR,8S,10S,11R,11aS,12S,12aS,13aR)-7,8,12-tris(acetyloxy)-1,2a,5,7,7a,8,9,10,11,11a,12,13a-dodecahydro-10-hydroxy-4,7a,11,13a-tetramethyl-1-oxo-6H-benzo[4,5]cyclodec[1,2-b]oxireno[c]furan-6-yl ester

参考文献

1. Wan-Chi Hsiao, et al. Commun Chem. 2023 Jul 18;6(1):153.

2. Niu GH, et al. J Med Chem. 2025 Feb 27. doi: 10.1021/acs.jmedchem.4c02665.

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