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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Fungal-Econazole
Econazole

Chemical Structure : Econazole

CAS No.: 27220-47-9

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Econazole ((±)-Econazol)

货号: PC-27955Not For Human Use, Lab Use Only.

Econazole is an imidazole derivative broad-spectrum antifungal agent, inhibits lanosterol 14α-demethylase, a key enzyme in the ergosterol synthesis pathway, also is a Ca2+ channel antagonist, induces cytotoxicity in leukemia cells, induces p53-dependent apoptosis and decreases metastasis ability in gastric cancer cells.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Econazole is an imidazole derivative broad-spectrum antifungal agent, inhibits lanosterol 14α-demethylase, a key enzyme in the ergosterol synthesis pathway, also is a Ca2+ channel antagonist, induces cytotoxicity in leukemia cells, induces p53-dependent apoptosis and decreases metastasis ability in gastric cancer cells.

物理化学性质&存储条件

分子量 381.68
分子式 C18H15Cl3N2O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-(2-((4-Chlorobenzyl)oxy)-2-(2,4-dichlorophenyl)ethyl)-1H-imidazole

参考文献

1. Thienpont D, et al. Arzneimittelforschung. 1975 Feb;25(2):224-30.

2. Heel RC, et al. Drugs. 1978 Sep;16(3):177-201.

3. Choi EK, et al. Biomol Ther (Seoul). 2020 Jul 1;28(4):370-379.

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