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首页-抗体药物偶连体和PROTACs-PROTAC-ERD-308
ERD-308

Chemical Structure : ERD-308

CAS No.: 2320561-35-9

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ERD-308 (ERD308)

货号: PC-73165Not For Human Use, Lab Use Only.

ERD-308 (ERD308) is a highly potent estrogen receptor (ER) PROTAC degrader with DC50 of 0.17 and 0.43 nM in MCF-7 and T47D ER+ breast cancer cell lines, respectively.

规格 价格 库存 数量
5 mg ￥2580 In stock
25 mg ￥6280 In stock
100 mg ￥15800 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

ERD-308 (ERD308) is a highly potent estrogen receptor (ER) PROTAC degrader with DC50 of 0.17 and 0.43 nM in MCF-7 and T47D ER+ breast cancer cell lines, respectively.
ERD-308 induces >95% of ER degradation at concentrations as low as 5 nM in MCF-7 and T47D ER+ breast cancer cell lines.
ERD-308 induces more complete ER degradation than fulvestrant, the only approved selective ER degrader (SERD), and is more effective in inhibition of cell proliferation than fulvestrant in MCF-7 cells.

物理化学性质&存储条件

分子量 1004.26
分子式 C55H65N5O9S2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 Month
Shipping
Solubility

Chemical Name/SMILES

参考文献

1. Jiantao Hu, et al. J Med Chem. 2019 Feb 14;62(3):1420-1442.

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