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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Parasite-ELQ-316
ELQ-316

Chemical Structure : ELQ-316

CAS No.: 1354745-69-9

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ELQ-316 (ELQ316)

货号: PC-24760Not For Human Use, Lab Use Only.

ELQ-316 is a potent, orally bioavailable inhibitor of T. gondii growth in vitro (IC50=0.007 nM) and is effective against acute and latent toxoplasmosis in mice, inhibits cytochrome c reduction by the T. gondii cytochrome bc(1) complex.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

ELQ-316 is a potent, orally bioavailable inhibitor of T. gondii growth in vitro (IC50=0.007 nM) and is effective against acute and latent toxoplasmosis in mice, inhibits cytochrome c reduction by the T. gondii cytochrome bc(1) complex.
ELQ-316 has ED(50) value of 0.08 mg/kg when administered orally to mice with acute toxoplasmosis.
ELQ-316 is highly active against the cyst form of T. gondii in mice at low doses, reducing cyst burden by 76-88% after 16 d of treatment.

物理化学性质&存储条件

分子量 459.40
分子式 C24H17F4NO4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4(1H)-Quinolinone, 6-fluoro-7-methoxy-2-methyl-3-[4-[4-(trifluoromethoxy)phenoxy]phenyl]-

参考文献

1. Doggett JS, et al. Proc Natl Acad Sci U S A. 2012 Sep 25;109(39):15936-41.

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