EBET-1055 | BET degrader | Probechem Biochemicals

Chemical Structure : EBET-1055

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EBET-1055 (ER-001326054-000, EBET1055)

货号: PC-22215Not For Human Use, Lab Use Only.

EBET-1055 is a bromodomain and extra-terminal (BET) protein degrader, effectively kills PDAC cells, and modulates cancer-associated fibroblasts (CAFs) in PDAC.

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生物&药学活性

EBET-1055 is a bromodomain and extra-terminal (BET) protein degrader, effectively kills PDAC cells, and modulates cancer-associated fibroblasts (CAFs) in PDAC.
EBET-1055 is highly potent in both PC-3 and PC-42 organoids.
EBET-1055 is composed of BET inhibitor (EBET-590), an E3 ubiquitin ligase ligand, and a linker.
EBET-1055 decreased the phosphorylation levels of STAT3 Y705, SMAD2 S465/467, and SMAD3 S423/425 in PDAC cells.

物理化学性质&存储条件

分子量	923.04
分子式	C51H54N8O9
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(2-(4-((1-(4-(1-cyclopropoxy-2-hydroxy-1-phenylethyl)-6-(1,5-dimethyl-6-oxo-1,6-dihydropyridin-3-yl)quinazolin-2-yl)piperidin-4-yl)methyl)piperazin-1-yl)-2-oxoethoxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione

参考文献

1. Nakazawa Y, et al. Nat Commun. 2024 Mar 11;15(1):2192.

EBET-1055 (ER-001326054-000, EBET1055)

生物&药学活性

物理化学性质&存储条件

参考文献

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EBET-1055 (ER-001326054-000, EBET1055)

生物&药学活性

物理化学性质&存储条件

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