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首页-小分子抑制剂&激动剂-GPCR-Adrenergic Receptor-Doxazosin
Doxazosin

Chemical Structure : Doxazosin

CAS No.: 74191-85-8

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Doxazosin (UK 33274)

货号: PC-27221Not For Human Use, Lab Use Only.

Doxazosin is a long-lasting, selective antagnist of α1-adrenoceptor antagonist receptors, shows potent apoptotic effect against prostate tumor epithelial cells, also has direct inhibitory effect on cholesterol synthesis independent of the LDL receptor.

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50 mg ￥780 In stock
100 mg ￥1180 In stock
250 mg ￥1980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Doxazosin is a long-lasting, selective antagnist of α1-adrenoceptor antagonist receptors, shows potent apoptotic effect against prostate tumor epithelial cells, also has direct inhibitory effect on cholesterol synthesis independent of the LDL receptor.

物理化学性质&存储条件

分子量 451.48
分子式 C23H25N5O5
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(4-(4-Amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl)(2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methanone

参考文献

1. Tsukiyama H, et al. Drugs. 1988;36 Suppl 6:48-54.

2. Miura Y, et al. Am Heart J. 1988 Dec;116(6 Pt 2):1785-9.

3. Benning CM, et al. Cancer Res. 2002 Jan 15;62(2):597-602.

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